Resveratol, vino in kapsule (2.del)

Zdravi, močni in lepi.

zdravje: gibanje in športna prehrana, avtor: Alexander 

Medtem, ko so lahko atleti brez dvoma navdušeni nad učinki resveratrola, kot je zvišanje ravni testosterona in znižanje estrogena po naravni poti, so se ljudje, ki bi radi izboljšali kvaliteto svojega življenja, lotili uporabe resveratrola iz povsem drugih razlogov.

istock_000009001763xsmall

Obsežna literatura, ki opisuje resveratrol, navaja različne pozitivne učinke. Resveratrol blagodejno vpliva na srčno žilni sistem, zavira procese staranja, učinkuje proti raku, proti artritisu in ima druge pozitivne učinke na živčni sistem (npr. potencialne koristi pri zdravljenju Alzheimerjeve bolezni). Mnogi zgoraj našteti učinki izhajajo iz antioksidativnega in protivnetnega delovanja resveratrola, kot tudi genske modulacije.(13-21) Posamezniki, ki bi radi izboljšali kvaliteto svojega življenja, so najbolj navdušeni nad tem, da resveratrol dejansko lahko podaljša življenjsko dobo. Se spomnite primerov stradanja, ko so ljudje verjeli, da lahko znatno podaljšajo življenjsko dobo, če bi dnevno zaužili zelo majhno količino kalorij? Specifičen mehanizem v telesu, s katerim lahko z odvzemom kalorij živimo dlje obstaja, ta mehanizem aktivira beljakovino, imenovano SIRT1 (sirtuin 1). Aktiviranje teh beljakovin zavira PPAR-gama (hormonski receptor ali kemični sporočevalec) aktivnost, kar povzroči, da telo kuri nakopičeno telesno maščobo. Ni si težko predstavljati, da bi z manj maščobe lahko živeli dlje, vendar je presenetljivo, da resveratrol aktivira prav to SIRT1 beljakovino. Torej, tudi če si na tej točki ne razbijate glave s tem, kako podaljšati svoje življenje, lahko resveratrol kuri telesno maščobo namesto vas. Mogoče ste že slišali za t.i. francoski paradoks? To je prava uganka medicine, kjer imajo nekatere populacije (Francozi in Grki) presenetljivo nizek odstotek obolevnosti za srčno-žilnimi boleznimi, kljub temu, da jedo hrano z visoko vsebnostjo nasičenih maščob. Epidemiologi so dokazali, da razlog tiči v kulturi pitja rdečega vina. Mnogi raziskovalci so šli še korak dlje in ugotovili, da je resveratrol v vinu tisti, ki je odgovoren za t.i. francoski paradoks.(22-25) Za to skoraj čudežno snov je bilo dokazano, da ima tudi proti-glivične in proti-virusne lastnosti in lahko celo zaščiti jetra zaradi pretiranega uživanja alkohola ali oksidativnih poškodb zaradi prevelikih odmerkov Paracetamola (to je pogost pojav v ZDA).(26-39) Obstaja precej podatkov, ki dokazujejo, da je resveratrol sestavina, ki veliko obeta na področju preprečevanja in zdravljenja raka prostate!(40-48)

Pozitivne lastnosti Resveratola:

  • Deluje ravno nasprotno kot estrogen in zavira aromatizacijo. 
  • Povečuje testosteron brez da bi se ob tem zmanjšala produkcija le tega v testisih 
  • Krepi zdravje srca in ožilja 
  • Anti-kancerogeno delovanje - zavira nastanek rakavih celic, še posebej maligne spremembe prostate
  • Zavira staranje 
  • Spodbuja izgubo maščobe 
  • Deluje protivnetno 
  • Antioksidativno delovanje (deluje kot antioksidant)
  • Zavira nastanek artritisa
  • Proti-glivični in proti-virusni učinki 
  • Ščiti jetra

Reference:

1. Juan ME, et al. "trans-Resveratrol, a natural antioxidant from grapes, Increases sperm output in healthy rats." J Nutr. 2005 Apr;135(4):757-60.

2. Bhat KP, et al. "Estrogenic and antiestrogenic properties of resveratrol in mammary tumor models." Cancer Res. 2001 Oct 15;61(20):7456-63.

3. Henry LA, Witt DM. "Resveratrol: phytoestrogen effects on reproductive physiology and behavior in female rats." Horm Behav. 2002 Mar;41(2):220-8.

4. Matsumura A, Ghosh A, Pope GS, Darbre PD. "Comparative study of oestrogenic properties of eight phytoestrogens in MCF7 human breast cancer cells." J Steroid Biochem Mol Biol. 2005 Apr;94(5):431-43.

5. Bowers JL, et al. "Resveratrol acts as a mixed agonist/antagonist for estrogen receptors alpha and beta." Endocrinology. 2000 Oct;141(10):3657-67.

6. Lu R, Serrero G. "Resveratrol, a natural product derived from grape, exhibits antiestrogenic activity and inhibits the growth of human breast cancer cells." J Cell Physiol. 1999 Jun;179(3):297-304.

7. Turner RT, et al. "Is resveratrol an estrogen agonist in growing rats?" Endocrinology. 1999 Jan;140(1):50-4.

8. Bhat KP, Pezzuto JM. "Resveratrol exhibits cytostatic and antiestrogenic properties with human endometrial adenocarcinoma (Ishikawa) cells." Cancer Res. 2001 Aug 15;61(16):6137-44.

9. Wang Y, et al. "The Red Wine Polyphenol Resveratrol Displays BI-Level Inhibition on Aromatase in Breast Cancer Cells." Toxicol Sci. 2006 Apr 11; E-Published Ahead of Print

10. Wallerath T, et al. "A blend of polyphenolic compounds explains the stimulatory effect of red wine on human endothelial NO synthase." Nitric Oxide. 2005 Mar;12(2):97-104.

11. Lekakis J, et al. "Polyphenolic compounds from red grapes acutely improve endothelial function in patients with coronary heart disease." Eur J Cardiovasc Prev Rehabil. 2005 Dec;12(6):596-600.

12. Buluc M, Demirel-Yilmaz E. "Resveratrol decreases calcium sensitivity of vascular smooth muscle and enhances cytosolic calcium increase in endothelium." Vascul Pharmacol. 2006 Apr;44(4):231-7.

13. Labinskyy N, et al. "Vascular dysfunction in aging: potential effects of resveratrol, an anti-inflammatory phytoestrogen." Curr Med Chem. 2006;13(9):989-96.

14. Bhat KPL, et al. "Biological effects of resveratrol." Antioxid Redox Signal. 2001 Dec;3(6):1041-64.

15. Bradamante S, et al. "Cardiovascular protective effects of resveratrol." Cardiovasc Drug Rev. 2004 Fall;22(3):169-88.

16. de la Lastra CA & Villegas I. "Resveratrol as an anti-inflammatory and anti-aging agent: mechanisms and clinical implications." Mol Nutr Food Res. 2005 May;49(5):405-30.

17. Delmas D, Jannin B, Latruffe N. "Resveratrol: preventing properties against vascular alterations and ageing." Mol Nutr Food Res. 2005 May;49(5):377-95.

18. Valenzano DR, et al. "Resveratrol prolongs lifespan and retards the onset of age-related markers in a short-lived vertebrate." Curr Biol. 2006 Feb 7;16(3):296-300.

19. Marambaud P, Zhao H, Davies P. "Resveratrol promotes clearance of Alzheimer's disease amyloid-beta peptides." J. Biol. Chem 2005 Nov;280(45): 37377-37382

20. Molnar V, Garai J. "Plant-derived anti-inflammatory compounds affect MIF tautomerase activity." Int Immunopharmacol. 2005 May;5(5):849-56.

21. Elmali N, et al. "Effect of resveratrol in experimental osteoarthritis in rabbits." Inflamm Res. 2005 Apr;54(4):158-62.

22. Kopp P. "Resveratrol, a phytoestrogen found in red wine. A possible explanation for the conundrum of the 'French paradox'?" Eur J Endocrinol. 1998 Jun;138(6):619-20.

23. Constant, J. "Alcohol, ischemic heart disease, and the French paradox." Coron. Artery Dis. 1997; 8:645 – 649.

24. Das, D K, et al. "Cardioprotection of red wine: role of polyphenolic antioxidants." Drugs Exp Clin Res. 1999;25(2-3):115-20.

25. Soleas GJ, Diamandis EP, Goldberg DM. "The world of resveratrol." Adv Exp Med Biol. 2001;492:159-82.

26. Wyke SM, Tisdale MJ. "Induction of protein degradation in skeletal muscle by a phorbol ester involves upregulation of the ubiquitin-proteasome proteolytic pathway." 2006 May;78(25):2898-2910

27. Tisdale MJ. "The ubiquitin-proteasome pathway as a therapeutic target for muscle wasting." J Support Oncol. 2005 May-Jun;3(3):209-17.

28. Wyke SM, Russell ST, Tisdale MJ. "Induction of proteasome expression in skeletal muscle is attenuated by inhibitors of NF-kappaB activation." Br J Cancer. 2004 Nov 1;91(9):1742-50.

29. Borra MT, Smith BC, Denu JM. "Mechanism of human SIRT1 activation by resveratrol." J Biol Chem. 2005 Apr 29;280(17):17187-95.

30. Picard F, et al. "Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma." Nature. 2004 Jun 17;429(6993):771-6.

31. Wolf G. "Calorie restriction increases life span: a molecular mechanism." Nutr Rev. 2006 Feb;64(2 Pt 1):89-92.

32. Ingram DK, et al. "Calorie restriction mimetics: an emerging research field." Aging Cell. 2006 Apr;5(2):97-108.

33. Roth GS, Lane MA, Ingram DK. "Caloric restriction mimetics: the next phase." Ann N Y Acad Sci. 2005 Dec;1057:365-71.

34. Tian WX. "Inhibition of fatty acid synthase by polyphenols." Curr Med Chem. 2006;13(8):967-77.

35. Kasdallah-Grissa A, et al. "Protective effect of resveratrol on ethanol-induced lipid peroxidation in rats." Alcohol Alcohol. 2006 May-Jun;41(3):236-9

36. Sener G, et al. "Protective effects of resveratrol against acetaminophen-induced toxicity in mice." Hepatol Res. 2006 Apr 1; E-Published Ahead of Print

37. Docherty JJ, et al. "Effect of resveratrol on herpes simplex virus vaginal infection in the mouse." Antiviral Res. 2005 Sep;67(3):155-62.

38. Jung HJ, et al. "Fungicidal effect of resveratrol on human infectious fungi." Arch Pharm Res. 2005 May;28(5):557-60.

39. Palamara AT, et al. "Inhibition of influenza A virus replication by resveratrol." J Infect Dis. 2005 May 15;191(10):1719-29.

40. Yoo KM, et al. "Potent Inhibitory Effects of Resveratrol Derivatives on Progression of Prostate Cancer Cells." Arch Pharm (Weinheim). 2006 Apr 18;339(5):238-241

41. Jones SB, et al. "Resveratrol-induced gene expression profiles in human prostate cancer cells." Cancer Epidemiol Biomarkers Prev. 2005 Mar;14(3):596-604.

42. Scifo C, et al. "Resveratrol and propolis as necrosis or apoptosis inducers in human prostate carcinoma cells." Oncol Res. 2004;14(9):415-26.

43. Kim YA, et al. "Antiproliferative effect of resveratrol in human prostate carcinoma cells." J Med Food. 2003 Winter;6(4):273-80.

44. Stewart JR, Artime MC, O'Brian CA. "Resveratrol: a candidate nutritional substance for prostate cancer prevention." J Nutr. 2003 Jul;133(7 Suppl):2440S-2443S.

45. Ratan HL, et al. "Resveratrol – a prostate cancer chemopreventive agent?" Urol Oncol. 2002 Nov-Dec;7(6):223-7.

46. Aggarwal BB, et al. "Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies." Anticancer Res. 2004 Sep-Oct;24(5A):2783-840.

47. Aziz MH, Kumar R, Ahmad N. "Cancer chemoprevention by resveratrol: in vitro and in vivo studies and the underlying mechanisms (review)." Int J Oncol. 2003 Jul;23(1):17-28.

48. Delmas D, et al. "Resveratrol as a chemopreventive agent: a promising molecule for fighting cancer." Curr Drug Targets. 2006 Apr;7(4):423-42.

 

Forumi (vroče teme)

Kaj jutri za kosilo?Dragička
malo za hecsijasaja
MOJ vrtrdkapica
Kaj danes za zajtrkjohana
Ločevanje živil 90. dni - 5. deldočka

Video recepti

Dnevna potreba po energiji

kg
cm
let

Več formul »